Background：Acts as a cofactor for complement factor I,a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
仕様
Synonyms：AHUS2,Antigen defined by monoclonal TRA 2 10,Antigen identified by monoclonal TRA 2 10,CD46,CD46 antigen,CD46 antigen complement regulatory protein,CD46 molecule,CD46 molecule complement regulatory protein,Complement membrane cofactor protein,MCP,MCP,Measles virus receptor,membrane cofactor protein （CD46,trophoblast-lymphocyte cross-reactive antigen）,Membrane cofactor protein,MGC26544,MIC10,TLX,TRA2.10,Trophoblast leucocyte common antigen,Trophoblast leukocyte common antigen,Trophoblast lymphocyte cross reactive antigen
Host：Rabbit
Reactivity：Mouse,Rat
Applications：IHC
Concentration：2mg/mL
Immunogen：Recombinant human Membrane cofactor protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
