Background：Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules （BGs）; is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate （KS） and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 （HIV-1） infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
仕様
Synonyms：C type lectin domain family 4 member K,C-type lectin domain family 4 member K,CD 207,CD207,CD207 antigen,CD207 antigen,langerin,CD207 molecule,CLC4K,CLEC 4K,CLEC4K,Langerhans cell specific c type lectin,Langerin,RGD1565913
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC
Concentration：2mg/mL
Immunogen：Recombinant human C-type lectin domain family 4 member K protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
