86-4054-67 ［取扱停止］Recombinant Human B7-H6 Protein (His Tag)(Active) 200ug PKSH030461
[Elabscience]
特徴
- 背景：Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.
仕様
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- 遺伝子構造：A DNA sequence encoding the human NCR3LG1 (NP_001189368.1) (Met1-Ser262) was expressed with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：B7-H6;B7H6;DKFZp686O24166
- アミノ酸配列：Met 1-Ser262
- アクセッションＮｏ．：NP_001189368.1
- タグ種類：C-His
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- 分子量：28.1 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-37247-elabscience-PKSH030461.pdf
- サイズ：200ug
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| 商品イメージ | アズワン品番 商品名 |
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86-4051-46
Recombinant Human B7-H6 Protein (His Tag)(Active) 50ug
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86-4054-67
Recombinant Human B7-H6 Protein (His Tag)(Active) 200ug
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