86-4052-72 ［取扱停止］Recombinant Human DPP4/CD26 Protein(Active) 20ug PKSH033811
[Elabscience]
特徴
- 背景：Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes.
仕様
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 70 % as determined by SDS-PAGE
- 遺伝子構造：The native mature form of human DPPIV (NP_001926.2) extracellular domain (Asn 29-Pro 766) was expressed and purified.
- 別名（遺伝子名）：ADABP Protein, Human; ADCP2 Protein, Human; CD26 Protein, Human; DPPIV Protein, Human; TP103 Protein, Human
- アミノ酸配列：Asn29-Pro766
- アクセッションＮｏ．：NP_001926.2
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- 分子量：85.4kDa
- 組成：Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.Please refer to the specific buffer information in the printed manual.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-239223-elabscience-PKSH033811.pdf
- サイズ：20ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4052-72
Recombinant Human DPP4/CD26 Protein(Active) 20ug
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86-4051-74
Recombinant Human DPP4/CD26 Protein(Active) 10ug
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