86-4052-71 Recombinant Human CD147/Basigin Protein (His Tag) 100ug PKSH031784
[Elabscience]
特徴
- 背景：CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
仕様
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-His 205) of human CD147 (NP_940991.1) precursor was expressed with the fused polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：5F7;Basigin;CD147;EMMPRIN;M6;OK;TCSF
- アミノ酸配列：Met 1-His 205
- アクセッションＮｏ．：NP_940991.1
- タグ種類：C-His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：21.6 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-38175-elabscience-PKSH031784.pdf
- サイズ：100ug
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86-4052-71
Recombinant Human CD147/Basigin Protein (His Tag) 100ug
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86-4051-73
Recombinant Human CD147/Basigin Protein (His Tag) 50ug
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