86-4052-17 Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5 50ug PKSH033872
[Elabscience]
特徴
- 背景：Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
仕様
- 種由来：Human
- 発現宿主：E.coli
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Human Interleukin-36 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Val2-Asp155 is expressed.
- 別名（遺伝子名）：Interleukin-36 Receptor Antagonist Protein; FIL1 Delta; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 HY1; IL-1HY1; Interleukin-1 Delta; IL-1 Delta; Interleukin-1 Family Member 5; IL-1F5; Interleukin-1 Receptor Antagonist Homolog 1; IL-1ra Homolog 1; Interleukin-1-Like Protein 1; IL-1L1; IL36RN; FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3
- アミノ酸配列：Val2-Asp155
- アクセッションＮｏ．：Q9UBH0
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：16.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463336-elabscience-PKSH033872.pdf
- サイズ：50ug
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| 商品イメージ | アズワン品番 商品名 |
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86-4052-17
Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5 50ug
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86-4048-17
Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5 10ug
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