特徴
- 背景：Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.
仕様
- 種由来：Human
- 発現宿主：E.coli
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 is produced by our E.coli expression system and the target gene encoding Met1-His520 is expressed with a 6His tag at the N-terminus.
- 別名（遺伝子名）：IPFK2; PFK2; iPFK-2; PFK/FBPase 3
- アミノ酸配列：Met1-His520
- アクセッションＮｏ．：Q16875
- タグ種類：N-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：61.8 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 50mM KCl, 1mM DTT, 0.1mM EDTA, 20% Glycerol, pH 8.0.
- 保存条件：Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463435-elabscience-PKSH033971.pdf
- サイズ：50ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4048-15
Recombinant Human PFKFB3 (N-6His) 10ug
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86-4052-13
Recombinant Human PFKFB3 (N-6His) 50ug
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