86-4050-46 Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated 20ug PKSH033997
[Elabscience]
特徴
- 背景：Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.
仕様
- 種由来：Human
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.
- 別名（遺伝子名）：Butyrophilin subfamily 2 member A2; BTN2A2
- アミノ酸配列：Gln33-Val237
- アクセッションＮｏ．：Q8WVV5
- タグ種類：C-Fc-Avi
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：51.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463461-elabscience-PKSH033997.pdf
- サイズ：20ug
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