86-4050-45 Recombinant Human Neuropilin-1/NRP1 (C-Avi-6His) Biotinylated 20ug PKSH033988
[Elabscience]
特徴
- 背景：Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors.
仕様
- 種由来：Human
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Biotinylated Recombinant Human Neuropilin-1 is produced by our Mammalian expression system and the target gene encoding Phe22-Lys644 is expressed with a Avi, 6His tag at the C-terminus.
- 別名（遺伝子名）：CD304; NRP1; NRPNP1; VEGF165R; BDCA4
- アミノ酸配列：Phe22-Lys644
- アクセッションＮｏ．：AAH07533.1
- タグ種類：C-Avi-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：72.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463452-elabscience-PKSH033988.pdf
- サイズ：20ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4054-34
Recombinant Human Neuropilin-1/NRP1 (C-Avi-6His) Biotinylated 100ug
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86-4050-45
Recombinant Human Neuropilin-1/NRP1 (C-Avi-6His) Biotinylated 20ug
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