86-4050-13 Recombinant Human PDCD1/PD-1/CD279 (C-6His-Avi) Biotinylated 20ug PKSH033853
[Elabscience]
特徴
- 背景：Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
仕様
- 種由来：Human
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Biotinylated Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His, Avi tag at the C-terminus.
- 別名（遺伝子名）：Programmed cell death protein 1; hPD-1; PDCD1; CD279
- アミノ酸配列：Pro21-Gln167
- アクセッションＮｏ．：Q15116
- タグ種類：C-6His-Avi
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：19.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463317-elabscience-PKSH033853.pdf
- サイズ：20ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4054-01
Recombinant Human PDCD1/PD-1/CD279 (C-6His-Avi) Biotinylated 100ug
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86-4050-13
Recombinant Human PDCD1/PD-1/CD279 (C-6His-Avi) Biotinylated 20ug
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