背景：S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
仕様
種由来：Mouse
発現宿主：E.coli
純度：>95% as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding the Mouse S100a9(P31725) (2A-113K) was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：Leukocyte L1 complex heavy chain,60B8AG,CAGB,Calgranulin B,Calgranulin-B,Calprotectin L1H subunit,CFAG,CGLB,Cystic fibrosis antigen B,L1AG,Leukocyte L1 complex heavy chain,LIAG,MAC387,MIF,Migration inhibitory factor related protein 14,Migration inhibitory factor-related protein 14,MRP 14,MRP-14,MRP14,Myeloid-related protein 14,NIF,OTTHUMP00000015331,p14,Protein S100-A9,S100 A9,S100 calcium binding protein A9,S100 calcium binding protein A9 calgranulin B,S100 calcium-binding protein A9,S100A9,S10A9
アミノ酸配列：2A-113K
アクセッションＮｏ．：P31725
タグ種類：N/C-His
エンドトキシン濃度：Not tested.
分子量：14.3kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
