背景：Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation . Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress .
仕様
種由来：Mouse
発現宿主：E.coli
純度：>90% as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding theMouse Chromogranin-A/Chga(P26339) (457Ile-717Leu) was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：beta Granin,betagranin (N-terminal fragment of chromogranin A),catestatin,CgA,CHG A,Chga,chromofungin,Chromogranin A,Chromogranin A parathyroid secretory protein 1,Chromogranin A precursor,ChromograninA,CMGA,ER-37,Pancreastatin,Parastatin,Parathyroid secretory protein 1,Pituitary secretory protein I,Secretory protein I,SP I,SP-I,SP1,SPI,Vasostatin,Vasostatin I,Vasostatin II
アミノ酸配列：457Ile-717Leu
アクセッションＮｏ．：P26339
タグ種類：N/C-His
エンドトキシン濃度：Not tested.
分子量：31kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
