背景：Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.
仕様
種由来：Human
発現宿主：E.coli
純度：>90% as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding the Human PDCD4(Q53EL6) (1M-325N) was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：Death up-regulated gene protein,Dug,H731,Ma3,MGC33046,MGC33047,Neoplastic transformation inhibitor,Neoplastic transformation inhibitor protein,Nuclear antigen H731,Nuclear antigen H731 like,Nuclear antigen H731 like protein,Nuclear antigen H731-like,PDCD 4,Pdcd4,PDCD4,Programmed cell death 4,programmed cell death 4 (neoplastic transformation inhibitor),Programmed cell death protein 4,Protein 197/15a,Protein MA-3,Tis,Topoisomerase-inhibitor suppressed protein
アミノ酸配列：1M-325N
アクセッションＮｏ．：Q53EL6
タグ種類：N/C-His
エンドトキシン濃度：Not tested.
分子量：36.9kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
