背景：PTEN (also designated MMAC1),products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
仕様
種由来：Human
発現宿主：E.coli
純度：>85 % as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding the Human PTEN (P60484-1) (Thr2-Val403) was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：10q23del;BZS;DEC;GLM2;MGC11227;MHAM;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;Phosphatase and tensin like protein;Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;Pten;PTEN;PTEN1;TEP1
アミノ酸配列：Thr2-Val403
アクセッションＮｏ．：P60484-1
タグ種類：N-His
エンドトキシン濃度：Not tested.
分子量：46.8 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
