背景：Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2 . Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
仕様
種由来：Human
発現宿主：E.coli
純度：>85 % as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding the Human IFNAR1 (P17181-1) (Lys28-Leu200) was expressed with a polyhistidine tag at the N-terminus.
別名（遺伝子名）：Interferon alpha/beta receptor 1;IFN-R-1 IFN-alpha/beta receptor 1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;CRF2-1;Type I interferon receptor 1;IFNAR
アミノ酸配列：Lys28-Leu200
アクセッションＮｏ．：P17181-1
タグ種類：N-His
エンドトキシン濃度：Not tested.
分子量：20 kDa
組成：Lyophilized from sterile PBS, pH 7.4
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
