背景：CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
仕様
種由来：Human
発現宿主：Human Cells
純度：>95% as determined by reducing SDS-PAGE.
遺伝子構造：Recombinant Human Tumor necrosis factor receptor superfamily member 8 is produced by our Mammalian expression system and the target gene encoding Phe19-Lys379 is expressed with a mFc tag at the C-terminus.
エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
分子量：64.8 kDa
組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
