背景：Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a wide variety of growth and differentiation processes including gastrulation, skeletal system development, and cardiac morphogenesis. BMP signaling through Activin RIA is enhanced by the direct interaction between Activin RIA and RGM-B/DRAGON, a BMP coreceptor that also associates with other type I and type II receptors. Activin RIA can additionally phosphorylate the coreceptor Endoglin and is required for the inhibitory effect of Endoglin on prostate cancer cell motility.
仕様
種由来：Human
発現宿主：Human Cells
純度：>95% as determined by reducing SDS-PAGE.
遺伝子構造：Recombinant Human Receptor Protein Serine/Threonine Kinase is produced by our Mammalian expression system and the target gene encoding Asp23Val124 is expressed with a Fc tag at the C-terminus.
別名（遺伝子名）：activin A receptor, type I; Activin RIA; ActivinRIA; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; ALK-2; FOP; SKR1; TSRI
アミノ酸配列：Asp23Val124
アクセッションＮｏ．：Q53SV1
タグ種類：C-Fc
エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
分子量：38.2 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
