特徴
- 背景：The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
仕様
- 種由来：2019-nCoV
- 発現宿主：Human Cells
- 純度：>90% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed with a 10His tag at the C-terminus.
- 別名（遺伝子名）：S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
- アクセッションＮｏ．：QHD43416.1
- タグ種類：C-10His
- エンドトキシン濃度：Please contact us for more information.
- 分子量：76.6kDa
- 組成：Supplied as a 0.2 μM filtered solution of PBS, pH 7.4
- 保存条件：Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-388690-elabscience-PKSV030278.pdf
- サイズ：50ug
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4055-15
Recombinant RSV (A, rsb1734) glycoprotein G / RSV-G Protein (95% Homology) (His Tag) 100ug
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86-4048-68
Recombinant 2019-nCoV S1 Protein (C-10His) 50ug
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