特徴
- 背景：Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Non-glycosylated prolactin is produced by the pituitary and packaged in storage granules before secretion, while glycosylated prolactin is reported to be constitutively secreted, have lower biological potency, and be removed from the circulation more quickly. Prolactin is synthesized mainly by the anterior pituitary in all mammals, where secretion is under tonic inhibition by hypothalamic dopamine. In humans, prolactin is also produced peripherally. Prolactin expression is low during early human pregnancy, but increases in late pregnancy. The prolactin receptor (PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. prolactin molecule is thought to bind two receptor molecules. In addition to its lactogenic activity, peripherally produced prolactin plays roles in breast and prostate cancer development, regulation of reproductive function, and immunoregulation.
仕様
- 種由来：Sheep
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Sheep Prolactin is produced by our Mammalian expression system and the target gene encoding Thr31-Cys229 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Prolactin; PRL
- アクセッションＮｏ．：P01240
- タグ種類：C-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：23.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463583-elabscience-PKSQ050097.pdf
- サイズ：10ug
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4048-66
Recombinant Sheep Prolactin/PRL (C-6His) 10ug
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86-4052-58
Recombinant Sheep Prolactin/PRL (C-6His) 50ug
|
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掲載カタログ情報
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