背景：K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
仕様
種由来：Human
発現宿主：E.coli
純度：>95% as determined by reducing SDS-PAGE.
遺伝子構造：Recombinant Human GTPase Kras4B is produced by our E.coli expression system and the target gene encoding Met1-Lys169 is expressed with a 6His tag at the N-terminus.
別名（遺伝子名）：Ki-Ras; c-K-ras; KRAS2; RASK2; CFC2
アミノ酸配列：Met1-Lys169
アクセッションＮｏ．：P01116-2
タグ種類：N-6His
エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
分子量：21.4 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
