特徴
- 背景：Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also known as PTPT and TC-PTP, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation.TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.
仕様
- 種由来：Human
- 発現宿主：E.coli
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E.coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：PTP2; PTPN2; PTPTPTN2; TCELLPTP; TCPTP; TC-PTP
- アミノ酸配列：Thr2-Asn314
- アクセッションＮｏ．：P17706
- タグ種類：C-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：37.4 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM HEPES, 300Mm NaCl, 1mM DTT, 10% Glycerol, pH 7.4.
- 保存条件：Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463445-elabscience-PKSH033981.pdf
- サイズ：10ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4051-75
Recombinant Human TCPTP/PTPN2 (C-6His) 50ug
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86-4047-75
Recombinant Human TCPTP/PTPN2 (C-6His) 10ug
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