特徴
- 背景：Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Human Notch-2 ECD (aa 26-530) shows 93%, 93%, 96% and 96% aa identity with the corresponding regions of mouse, rat, canine, and bovine Notch-2, respectively. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.
仕様
- 種由来：Human
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Human Neurogenic Locus Notch Homolog Protein 2 is produced by our Mammalian expression system and the target gene encoding Leu26-Gln530 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS
- アミノ酸配列：Leu26-Gln530
- アクセッションＮｏ．：Q04721
- タグ種類：C-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：54.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463487-elabscience-PKSH034023.pdf
- サイズ：10ug
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| 商品イメージ | アズワン品番 商品名 |
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86-4051-69
Recombinant Human Notch2 (C-6His) 50ug
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86-4047-71
Recombinant Human Notch2 (C-6His) 10ug
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