86-4047-63 Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-Fc) 10ug PKSM041404
[Elabscience]
特徴
- 背景：NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
仕様
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Mouse NKG2-D Type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Phe94 - Val232 is expressed with a Fc tag at the N-terminus.
- 別名（遺伝子名）：CD314; KLRK1;CD314 antigen;Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D
- アミノ酸配列：Phe94 - Val232
- アクセッションＮｏ．：O54709
- タグ種類：N-Fc
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：42.2 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463537-elabscience-PKSM041404.pdf
- サイズ：10ug
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| 商品イメージ | アズワン品番 商品名 |
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86-4047-63
Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-Fc) 10ug
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86-4051-61
Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-Fc) 50ug
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