特徴
- 背景：CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.
仕様
- 種由来：Human
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Human C-type Lectin Domain Family 4 Member M is produced by our Mammalian expression system and the target gene encoding Ser73-Glu376 is expressed with a 8His, Flag tag at the N-terminus.
- 別名（遺伝子名）：CD209L; CD209L1; CD299; CLEC4M; C-type lectin domain family 4, member M; DC-SIGN2; DCSIGNR; DC-SIGNR; HP10347; LSIGN; L-SIGN; C-type Lectin Domain Family 4 Member M
- アミノ酸配列：Ser73-Glu376
- アクセッションＮｏ．：Q9H2X3-8
- タグ種類：N-8His-Flag
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：37 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463454-elabscience-PKSH033990.pdf
- サイズ：10ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4051-59
Recombinant Human DC-SIGNR/CD299 (N-8His-Flag) 50ug
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86-4047-61
Recombinant Human DC-SIGNR/CD299 (N-8His-Flag) 10ug
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