86-4047-46 Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-Fc) 10ug PKSM041442
[Elabscience]
特徴
- 背景：The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.
仕様
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Mouse Leptin Receptor is produced by our Mammalian expression system and the target gene encoding Leu22-Gly839 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR
- アミノ酸配列：Leu22-Gly839
- アクセッションＮｏ．：P48356
- タグ種類：C-Fc
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：119.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463575-elabscience-PKSM041442.pdf
- サイズ：10ug
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-4047-46
Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-Fc) 10ug
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86-4051-41
Recombinant Mouse Leptin Receptor/LEPR/CD295 (C-Fc) 50ug
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