背景：Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.
仕様
種由来：Mouse
発現宿主：Human Cells
純度：>95% as determined by reducing SDS-PAGE.
遺伝子構造：Recombinant Mouse Interleukin-11 Receptor Subunit Alpha-1 is produced by our Mammalian expression system and the target gene encoding Ser24-Gln367 is expressed with a 6His tag at the C-terminus.
別名（遺伝子名）：IL-11 R alpha; IL11R alpha; IL11RA; IL-11Ra; Il11ra2; NR1
アミノ酸配列：Ser24-Gln367
アクセッションＮｏ．：Q64385
タグ種類：C-6His
エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
分子量：38.5 kDa
組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
