86-4046-99 Recombinant Human IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His) 10ug PKSH033859
[Elabscience]
特徴
- 背景：Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
仕様
- 種由来：Human&Mouse
- 発現宿主：Human Cells
- 純度：>95% as determined by reducing SDS-PAGE.
- 遺伝子構造：Recombinant Chimeric Human&Mouse Interleukin-23 is produced by our Mammalian expression system and the target gene encoding Arg20-Pro189&Met23-Ser335 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2
- アミノ酸配列：Arg20-Pro189&Met23-Ser335
- アクセッションＮｏ．：Q9NPF7&P43432
- タグ種類：C-6His
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- 分子量：56.9 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-463323-elabscience-PKSH033859.pdf
- サイズ：10ug
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86-4046-99
Recombinant Human IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His) 10ug
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86-4050-92
Recombinant Human IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His) 50ug
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