86-4045-52　［取扱停止］Phospho-PTPN11(Y542) Polyclonal Antibody 200uL　E-AB-68122

特徴

• 背景：The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

仕様

• 抗体タイプ：Phosphorylated antibody
• アプリケーション：WB,IHC
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：A phospho specific peptide corresponding to residues surrounding Y542 of human PTPN11
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：WB 1:500-1:2000 IHC 1:50-1:100
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-391374-Elabscience-E-AB-68122.pdf
• サイズ：200uL
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