86-4044-73　［取扱停止］Phospho-ABL1(Y245) Polyclonal Antibody 200uL　E-AB-68042

特徴

• 背景：This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

仕様

• 抗体タイプ：Phosphorylated antibody
• アプリケーション：IHC
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：A phospho specific peptide corresponding to residues surrounding Y245 of human ABL1
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：IHC 1:50-1:200
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-391294-Elabscience-E-AB-68042.pdf
• サイズ：200uL
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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