特徴
- 背景:NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
仕様
- 抗体タイプ:Polyclonal Antibody
- アプリケーション:WB
- 交差性:Human,Rat
- 宿主:Rabbit
- アイソタイプ:IgG
- 抗原:Recombinant fusion protein of human NUAK1 (NP_055655.1).
- 緩衝液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3
- 精製方法:Affinity purification
- 希釈倍率:WB 1:200-1:2000
- 標識:Unconjugated
- メーカーマニュアル:https://file.elabscience.com/viewpdf-390360-Elabscience-E-AB-67108.pdf
- サイズ:200uL
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL:06-6447-8641
- FAX:06-6447-8642
- E-mail:[email protected]
商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-4035-44
NUAK1 Polyclonal Antibody 200uL
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86-3954-36
NUAK1 Polyclonal Antibody 60uL
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86-4000-20
NUAK1 Polyclonal Antibody 120uL
|
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掲載カタログ情報
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