86-4034-75　［取扱停止］DMTF1 Polyclonal Antibody 200uL　E-AB-67034

特徴

• 背景：This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

仕様

• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB
• 交差性：Human
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：Recombinant fusion protein of human DMTF1 (NP_066968.3).
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：WB 1:500-1:2000
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-390286-Elabscience-E-AB-67034.pdf
• サイズ：200uL
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