86-4017-97　［取扱停止］Phospho-RAF1(S259) Polyclonal Antibody 120uL　E-AB-68165

特徴

• 背景：This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

仕様

• 抗体タイプ：Phosphorylated antibody
• アプリケーション：WB
• 交差性：Human,Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：A synthetic phosphorylated peptide around S259 of human RAF1 (NP_002871.1).
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：WB 1:500-1:2000
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-391417-Elabscience-E-AB-68165.pdf
• サイズ：120uL
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