86-3989-34　［取扱停止］NLRP3 Polyclonal Antibody 120uL　E-AB-65952

特徴

• 背景：This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

仕様

• 抗体タイプ：Polyclonal Antibody
• アプリケーション：IHC,IF
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：A synthetic peptide of human NLRP3 (NP_001120934.1).
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：IHC 1:50-1:200 IF 1:50-1:200
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-389204-Elabscience-E-AB-65952.pdf
• サイズ：120uL
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