86-3986-35　［取扱停止］FLT3 Polyclonal Antibody 120uL　E-AB-40475

特徴

• 背景：This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

仕様

• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：Recombinant Mouse Receptor-type tyrosine-protein kinase FLT3 protein
• 緩衝液：PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• 精製方法：Antigen Affinity Purification
• 希釈倍率：WB 1:1000-1:3000 IHC 1:100-1:300
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアル：https://file.elabscience.com/viewpdf-469124-Elabscience-E-AB-40475.pdf
• サイズ：120uL
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