86-3980-39　［取扱停止］PTEN Monoclonal Antibody 60uL　E-AB-65804

特徴

• 背景：This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

仕様

• 抗体タイプ：Monoclonal Antibody
• アプリケーション：WB
• 交差性：Human,Mouse,Rat
• 宿主：Mouse
• アイソタイプ：IgG
• 抗原：Recombinant fusion protein of human PTEN.
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：WB 1:500-1:1000
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-389056-Elabscience-E-AB-65804.pdf
• サイズ：60uL
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