86-3968-13　PE Anti-Human CD196/CCR6 Antibody[ G034E3] 100Tests　E-AB-F1158D

特徴

• 背景：CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

仕様

• 抗体タイプ：FC_Antibody
• アプリケーション：FCM
• 交差性：Human
• 宿主：Mouse
• アイソタイプ：Mouse IgG2b, kappa
• 緩衝液：PBS with 0.05% Proclin300, 1% BSA
• 標識：PE
• クローナリティ：Monoclonal
• メーカーマニュアルリンク：https://file.elabscience.com/viewpdf-172789-Elabscience-E-AB-F1158D.pdf
• サイズ：100Tests
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