背景：Fc epsilon RI alpha is a transmembrane protein belonging to the Ig superfamily. Fc epsilon RI alpha forms a tetrameric complex with one β and two gamma -subunits. The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via Fc epsilon RI alpha , mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the Fc epsilon RI alpha subunit.
![APC Anti-Mouse Fc epsilon RI alpha Antibody[MAR-1] 500Tests](https://aimg.as-1.co.jp/c/86/3965/79/86393868.jpg)