86-3965-22　［取扱停止］AF488 Anti-Human CD49d Antibody[BU49] 50 Tests　E-AB-F1040L

特徴

• 背景：CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

仕様

• 抗体タイプ：FC_Antibody
• アプリケーション：FCM
• 交差性：Human
• 宿主：Mouse
• アイソタイプ：Mouse IgG1, kappa
• 緩衝液：PBS with 0.05% Proclin300, 1% BSA
• 標識：AF488
• クローナリティ：Monoclonal
• メーカーマニュアルリンク：https://file.elabscience.com/viewpdf-134544-Elabscience-E-AB-F1040L.pdf
• サイズ：50 Tests
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