86-3954-13　［取扱停止］COL18A1 Polyclonal Antibody 60uL　E-AB-67082

特徴

• 背景：This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

仕様

• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB
• 交差性：Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 抗原：A synthetic peptide of human COL18A1 (NP_085059.2).
• 緩衝液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• 精製方法：Affinity purification
• 希釈倍率：WB 1:500-1:1000
• 標識：Unconjugated
• メーカーマニュアル：https://file.elabscience.com/viewpdf-390334-Elabscience-E-AB-67082.pdf
• サイズ：60uL
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