86-3940-87　［取扱停止］AF647 Anti-Mouse IL-17A Antibody[TC11-18H10.1] 50 ug　E-AB-F1199UM

特徴

• 背景：IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF- kappa B, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

仕様

• 抗体タイプ：FC_Antibody
• アプリケーション：ICFCM
• 交差性：Mouse
• 宿主：Rat
• アイソタイプ：Rat IgG1, kappa
• 緩衝液：PBS with 0.05% Proclin300, 1% BSA
• 標識：AF647
• クローナリティ：Monoclonal
• メーカーマニュアルリンク：https://file.elabscience.com/viewpdf-457272-Elabscience-E-AB-F1199UM.pdf
• サイズ：50 ug
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