MUSCULAR DYSTROPHY, CONGENITAL MEROSIN-DEFICIENT, 1A; MDC1A; Induced pluripotent stem cell line derived from fibroblast; Clinically affected; symptom onset before 2 years of age; elevated creatine kinase （200-2,000 IU/L）; diagnosis confirmed by muscle imaging and biopsy; abnormal white matter in brain by MRI/CT scan; head held up without assistance; turned in bed by age three years; no other milestones have been achieved; night time respiratory support; donor subject is a compound heterozygote： maternal allele has a 2 bp deletion in exon 14 of the LAMA2 gene （2049_2050delAG）; the paternal allele has a C＆amp;gt;T transition at nucleotide 7732 in exon 55 （7732C＆amp;gt;T） resulting in a premature stop at codon 2578 [Arg2578Ter （R2578X）].
