Meningeal cells surrounding the brain participate actively in the normal development of the central nervous system. For example, they play important roles in both stabilizing the extracellular matrix of the pial surface and by organizing the radial glial scaffold and the lamination of the cerebellar cortex. Selective pharmacological destruction of the meningeal cells during a critical ontogenetic period leads to specific malformation of both the cerbella cortex and dentate gyrus. Grafts of meningeal cells, which derived form meninges overlying the cerebral cortex, in adult rat spinal cord lesion promote axonal regrowth. In vitro study shows that meningeal cell chemotactically orient the migration of immature neurons.HMC from AcceGen Research Laboratories are isolated from human leptomeningi. HMC are cryopreserved at primary culture and delivered frozen. Each vial contains ＆gt;5×10^5 cells in 1 ml volume. HMC are characterized by immunofluorescent method with antibodies to fibronectin and negative to GFAP, alpha-smooth muscle actin and Thy 1.1. HMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HMC are guaranteed to further expand for 5 population doublings at the condition provided by AcceGen Research Laboratories.
