特異性：Human CD49b, Mr 200-210 kDa CD49b, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin alpha 2 chain. CD49b associates noncovalently with CD29, the integrin beta 1 subunit, to form the heterodimer integrin a2b1 that binds laminin and collagen. It is expressed on B and T lymphocytes, NK cells, monocytes, platelets, fibroblasts and long-term cultured T cells. CD49b/CD29 mediates the Mg++- dependent adhesion of platelets to collagen. It may also be utilized by fibroblasts for the reorganization of the collagen matrix during would healing.
