特異性:MAb T14 reacts with LPS of Fr. tularensis. There is no cross-reactivity with Y. pestis, Y. pseudotuberculosis, Y. enterdegree Colitica, V. cholera, E Coli, S. typhimurium, Fr. novicida, Br. melitensis, Br. abortus, Br. suis, Br. ovis, and Br. neotomae. MAb FB11 recognizes LPS of virulent and vaccine strains of Fr. tularensis. There is no crossreactivity with Fr. novicida, Br. abortus, Br. suis, Br. melitensis, Br. ovis, Y. pestis, Y. enterdegree Colitica, Y. pseudotuberculosis, E Coli, and V. cholerae. The binding site for MAb FB11 is ldegree Cated on the O-antigen polysaccharide chain which consists of tetrasaccharide fragments and has the following structure: -4)alpha-D-GalpNAcAN-(1-4)-alpha-DGalpNAcAN-(1-3)-beta-D-QuipNAc-(1-2)-beta-Quip4NFm-(1. Tetrasaccharide D-GalpNAcAN-(1-4)-alpha-D-GalpNAcAN-(1-3)-beta-D-QuipNAc-(1-2)-beta-D-Quip4NFm and trisaccharide D-GalpNAcAN-(1-3)-beta-D-QuipNAc-(1-2)-beta-D-Quip4NFm compete in ELISA for binding MAb FB11 with LPS of Fr. tularensis.