86-2271-84　NFkB Activating Kinase (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1) 0.1 mg　MBS604330

仕様

• サイズ：0.1 mg
• クローナリティ：Monoclonal
• アイソタイプ：IgG1
• クローン名：[4H209]
• ホスト：Mouse
• 反応性：Mouse
• 特異性：NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recently, a new IKK family member, TBK1 (TANK-binding kinase) has been identified (8). TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner.
• 純度：Affinity Purified Purified by Protein G affinity chromatography.
• 形状：Supplied as a liquid in PBS, 0.02% sodium azide.
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