86-1911-46　Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 0.05 mg　MBS245411

仕様

• サイズ：0.05 mg
• 遺伝子名：[SOCS3]
• クローナリティ：Monoclonal
• アイソタイプ：IgG2b
• クローン名：[SO1]
• ホスト：Mouse
• 反応性：Human
• 特異性：Recognizes suppressor of cytokine signaling 3 (SOCS3), a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies.
• 純度：Protein A Purified
• 形状：PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.
• 濃度：1 mg/ml
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