特異性：This item recognises ubiquitin, a 8.6kDa cytoplasmic and nuclear protein which is highly conserved across species. Ubiquitin functions as a protein modifier which covalently attaches to lysines as either a monomer or as a lysine-linked polymer. Attachment as a Lys-48 polymer usually leads to the target protein undergoing proteolytic degradation. Attachment as a monomer does not result in degradation and may be linked to functions including maintenance of chromatin structure, regulation of gene expression, stress response and DNA repair. Ubiquitin can be detected in both normal and diseased brain tissues including the neurofibrillary tangles of Alzheimers disease, Lewy bodies in Parkinsons disease and Pick bodies in Pick's disease.
