特異性：This item recognises human cyclin-dependent kinase inhibitor 2A (CDKN2A), a 16kDa protein belonging to the CDKN2 cyclin dependent kinase inhibitor family. CDKN2A acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
