特異性：This item recognises an epitope on the C-Terminal domain of Human Epidermal Growth Factor Receptor (EGFR, EGR-R), a 175 kDa transmembrane glycoprotein belonging to the ErbB receptor tyrosine kinase family. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut. EGFR is over expressed in a high proportion of breast cancer cells and in a range of other carcinomas, high level expression of EGFR is often associated with advanced disease and poor prognosis. Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome.
