特異性：This item detects an epitope within the C-terminal of human CD167, a Discoidin Domain Receptor (DDR) also known as DDR1. CD167, a receptor for collagen, is widely expressed in normal and transformed epithelial cells, and may regulate cell adhesion, proliferation and extracellular matrix remodelling. CD167 is a 125kD protein which is partially processed into a 62kD membrane-anchored beta-subunit and a 54kD soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation. CD167 has been demonstrated to be a direct transcriptional target of the p53 tumour suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumours.
